Given Imaging Announces New Data Underscore Value of ManoScan(TM) AR in Patients With Incontinence

New ManoScan(TM) AR 3D Allows Better Characterization of Anorectal Function

Press Release
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Nov 02, 2011

Given Imaging Ltd. (NASDAQ: GIVN), a world leader in GI medical devices and pioneer of capsule endoscopy, today announced two new studies highlighting the utilization of ManoScan AR to better measure muscular response in patients who suffer from anal motility disorders. The abstracts were presented at the American College of Gastroenterology 2011 Annual Scientific Meeting, taking place from October 28th through November 2nd at the Gaylord National Harbor Hotel & Conference Center in National Harbor, Maryland. Given Imaging is exhibiting at booth #1601 throughout the conference.

"High resolution manometry allows more precise interrogation of anorectal sphincter function compared to conventional manometry and has become an important tool in evaluating patients with pelvic floor disorders, particularly chronic constipation and fecal incontinence," said C. Prakash Gyawali, Professor of Medicine, Washington University in St. Louis. "This technology helps physicians correlate patient symptoms with anorectal sphincter abnormalities, providing for better management of these disorders."

A poster presentation, abstract P760, entitled, "Correlation of Manometry Findings to Obstetrical Risk Factors in Women with Anal Incontinence," led by Nina George, DO, Temple University School of Medicine, reviewed ManoScan AR findings in 156 women suffering from fecal incontinence, seeking a correlation among symptoms, medical co-morbidities and obstetrical risk factors. The researchers found that among these women, those who had previously given birth showed an increased risk of abnormal anal function, with vaginal birth mothers at higher risk than those who delivered by c-section. In addition, symptomatic anal incontinence was significantly worse in women who also experienced increased urinary incontinence.

ManoView AR

In an additional poster presentation, abstract P1169, entitled, "Anal Sphincter Complex Response after Rectal Balloon Distention at Different Sensation Thresholds," researchers from the University of Iowa Hospitals and Clinics reported a novel contractile response using ManoScan AR 3D. The study authors used three-dimensional high resolution manometry to compare the anal sphincter complex of ten healthy patients to sixteen patients suffering from either fecal incontinence or constipation. Using ManoScan AR 3D, the researchers observed a unique contractile response and significant differences in the anal function of the healthy patients versus those suffering from an anal disorder, both in response location as well as orientation. The authors recommend further studies to determine the precise role of this response in anorectal motility disorders.

ManoScan(TM) pioneered solid state high resolution manometry (HRM) and remains the market leader in comprehensive solutions for assessing gastrointestinal motility. Through the combination of proprietary tactile-sensing catheter technology and easy-to-use ManoView(TM) software, ManoScan reveals complex functional anatomy, enabling physicians to more accurately diagnose abnormalities of the gastrointestinal tract.

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